Young Scientist 2012 - Dr Nicholas Harvey
Dr Nicholas Harvey is a Senior Lecturer and Honorary Consultant Rheumatologist at the MRC Lifecourse Epidemiology Unit, University of Southampton, UK. He is currently working to develop novel public health strategies aimed at optimising intrauterine and childhood bone mineral accrual to reduce risk of osteoporosis-related fractures in older age. The centrepiece of this strategy is the MAVIDOS Maternal Vitamin D Osteoporosis Study, one of the first ever human investigations of the early life origins hypothesis, and which aims to test, in a randomised, placebo-controlled, double-blind setting, whether babies born to women supplemented with vitamin D through pregnancy will have greater bone mass at birth, assessed by DXA, than babies born to unsupplemented mothers. Dr Harvey has won several Young Investigator Awards at national and international meetings, published over 50 peer-reviewed papers, and is a member of the National Osteoporosis Society (UK) Scientific Programme Committee, Biobank Imaging Advisory Board, IOF Committee of Scientific Advisers, Scientific Advisory Board of ESCEO, and a past member of the Bone Research Society (UK) Committee. He serves as an academic editor for PLOS one, Frontiers in Bone Endocrinology and Archives of Public Health, and on the editorial board of Bone.
Kohn Prize 2010 -Dr Frank de Vries
Frank de Vries obtained a degree in pharmaceutical sciences from Utrecht University, the Netherlands, in 2002. Between 2002 and 2007, he has worked as a pharmacist, and undertook a PhD in pharmacoepidemiology. His PhD thesis was entitled “unintended effects of inhaled corticosteroids: disease or drugs?” In this PhD thesis, he has shown that there is probably not a causal relationship between exposure to high dose inhaled corticosteroids and risk of osteoporotic fracture. Dr de Vries analysed electronical medical records from >150,000 patients from the Netherlands, and the world’s largest primary care database: the UK General Practice Research Database. Instead, the severity of the underlying obstructive airway disease probably explained the observed doubled risk of hip fracture, as reported in previous studies.
In 2007, he published the first epidemiological study on the relationship between short courses of corticosteroids and risk of fracture: exposure to dosages up to 1 gram prednisolone equivalent in 1 year, probably do not increase risk of osteoporotic, hip or vertebral fracture. From 2007, Dr de Vries has been appointed at the MRC Epidemiology Resource Centre in Southampton and Utrecht University, the Netherlands. Until 2010, he has also worked as an epidemiologist at the Medicines and Healthcare products Regulatory Authority in London.
His current work pivots on the development of clinical risk scores for the prediction of fracture risk in patients with neurological disorders, users of psychiatric drugs, diabetes mellitus and osteoarthritis.
Kohn Prize 2009 - Dr Alireza Moayyeri
Alireza Moayyeri graduated as a Medical Doctor from Tehran University of Medical Sciences, Tehran, Iran in 2002. From 2003, he worked in the Endocrinology and Metabolism Research Centre of Tehran University as a research fellow working in the field of osteoporosis and evidence-based medicine. During this period he published several papers about the epidemiology of osteoporosis and hip fractures in Iran, diagnostic assessment of osteoporosis, and economic burden of hip fracture in Iran. During this time a collaboration, which is still ongoing, started with Dr. Bill Leslie from the Manitoba Bone Density Program, University of Manitoba, Winnipeg, Canada about precision assessment of DXA devices.
In 2006 Dr Moayyeri moved to the University of Cambridge to study for a Masters in epidemiology, on the relationship between respiratory function and the risk of fracture among the EPIC-Norfolk participants, under the supervision of Prof. Kay-Tee Khaw. He is currently undertaking a PhD which looks into the epidemiology and risk assessment of osteoporotic fractures in the EPIC-Norfolk study. He has developed a model based on Cox proportional-hazards regression for prediction of 10-year absolute risk of fracture and has applied this model for comparison of DXA and quantitative ultrasound in a subsample of EPIC-Norfolk and analysed other risk factors of osteoporosis including height loss, fat distribution and patterns of physical activity.
Dr Moayyeri has an excellent publication record (approximately 40 papers) in the field of epidemiology and osteoporosis.