﻿<?xml version='1.0' encoding='UTF-8'?><rss version="2.0" xmlns:dc="http://purl.org/dc/elements/1.1/"><channel><title>National Osteoporosis Society - Osteoporosis Forum / Osteoporosis Forums / General Chat </title><generator>InstantForum.NET v4.1.4</generator><description>National Osteoporosis Society - Osteoporosis Forum</description><link>http://www.nos.org.uk/forum/</link><webMaster>D.Hughes@nos.org.uk</webMaster><lastBuildDate>Sat, 18 May 2013 15:00:50 GMT</lastBuildDate><ttl>20</ttl><item><title>Body Fat</title><link>http://www.nos.org.uk/forum/Topic10256-11-1.aspx</link><description>The excessive body fat is bad for the health and can cause various illnesses such as being overweight, hypertension, diabetic issues, and many other illnesses.&lt;br&gt;The should be appropriate treatement to lose the extreme human extra fat, training and diets are more effective for the fat losing.</description><pubDate>Fri, 02 Nov 2012 16:49:52 GMT</pubDate><dc:creator>Buck333</dc:creator></item><item><title>Osteoporosis</title><link>http://www.nos.org.uk/forum/Topic11132-11-1.aspx</link><description>I would like to know how many forum members here have osteoporosis. &lt;br&gt;&lt;br&gt;Of course suppliers of kitchens etc might say they have OP when they don't :sick: so my poll may not be entirely accurate as it requires honesty :w00t:&lt;br&gt;&lt;br&gt;PS - if you are a relative of someone with osteoporosis do write in response to this poll to say why you ticked that you do not have osteoporosis.</description><pubDate>Wed, 06 Feb 2013 11:31:05 GMT</pubDate><dc:creator>AnneB</dc:creator></item><item><title>Kale</title><link>http://www.nos.org.uk/forum/Topic11482-11-1.aspx</link><description>The kale harvest has apparently failed ! I've not been able to buy it last week at neither Sainsburys nor Tescos, so I went to Waitrose today and they didn't have it either and informed me that the harvest had failed. I've had a bag of kale every day for the past five years - except when we've been on holiday - it's one of nature's 'superfoods' and full of calcium and magnesium, folic acid and other vitamins ! I shall have to have spring greens instead, not quite so super, and hope they grow some more kale quickly.&lt;br&gt;&lt;br&gt;A friend gave me a bunch of kale she had grown some time back and it was soooo beautiful I had to take a photo of it before I ate it - almost sad to cut it up. Here it is: &lt;br&gt;[img]http://dl.dropbox.com/u/8954651/DSC03672.jpg[/img]</description><pubDate>Wed, 13 Mar 2013 18:24:32 GMT</pubDate><dc:creator>AnneB</dc:creator></item><item><title>Best Sea Food</title><link>http://www.nos.org.uk/forum/Topic11824-11-1.aspx</link><description>Hello all, Here i am discuss about sea food , but i have little knowledge about this , so share with sea food is better and when i start to take , which type of benefits for me</description><pubDate>Sat, 13 Apr 2013 10:30:37 GMT</pubDate><dc:creator>jamsrich</dc:creator></item><item><title>Fundraising concert Weston super Mare</title><link>http://www.nos.org.uk/forum/Topic11841-11-1.aspx</link><description>Hi everyone&lt;br&gt;&lt;br&gt;As a regular "lurker" and occasional poster on these forums, and also a fellow sufferer, I am posting to let you know that I am holding a concert on Saturday 27 April in aid of my local OP support group. Those taking part will be some of my singing students and myself, with solos, duets, group items and plenty of comedy. There will be a substantial buffet during the interval when we sell raffle tickets in aid of our chosen charity. We sit around tables cabaret-style - all very casual. Audience members bring what they want to drink and we supply food and glasses. It starts at 7pm, finishing around 10.30 and is a jolly good night out for £10.&lt;br&gt;If anyone is from this area and is interested, please send me a message.&lt;br&gt;Thanks a lot!&lt;br&gt;&lt;br&gt;Eliza</description><pubDate>Tue, 16 Apr 2013 14:09:13 GMT</pubDate><dc:creator>Eliza</dc:creator></item><item><title>NHS Vitamin D Blood Test Change</title><link>http://www.nos.org.uk/forum/Topic11930-11-1.aspx</link><description>:ermm:&lt;/P&gt;&lt;P&gt;The nurse who took my blood said today when I queried, that the Vitamin D test is not put on ice straight away anymore, that the blood is taken straight to the lab.&lt;/P&gt;&lt;P&gt;I find this very odd and wondered if anyone else has come across the same recently?  Perhaps I have missed something in the news about the new way to test for vitamin D deficiency.&lt;/P&gt;&lt;P&gt;This is the first time this has happened, in previous tests the blood is put straight on ice.&lt;/P&gt;&lt;P&gt;Grateful for any feedback on this.&lt;/P&gt;&lt;P&gt;With thanks</description><pubDate>Mon, 22 Apr 2013 21:45:56 GMT</pubDate><dc:creator>OJ</dc:creator></item><item><title>Spine Curve</title><link>http://www.nos.org.uk/forum/Topic11784-11-1.aspx</link><description>Do the GP's do spine curve assessments or PT?</description><pubDate>Wed, 10 Apr 2013 13:51:39 GMT</pubDate><dc:creator>Bonetech999</dc:creator></item><item><title>Treatment/health</title><link>http://www.nos.org.uk/forum/Topic11637-11-1.aspx</link><description>I have asked on other matters on the osteoporosis forums, but need help on my wife's situation, she suffered 5 fractured vertebrae in mid December last year, no incident occurred just happened, .&lt;br&gt;We are now diagnosed as moderate to severe , but started 5 weeks now on alendronic treatment. &lt;br&gt;She is in constant pain and is taking slow release morphine twice a day , plus diazepam to relax her,  and paracetemol. She had bad constapation , but now is suffering diarrhoea everytime she goes to the loo. &lt;br&gt;Is this normal as her healing is very slow indeed. It is getting her down.&lt;br&gt;Any views please ?</description><pubDate>Thu, 28 Mar 2013 19:18:58 GMT</pubDate><dc:creator>Alanbbt</dc:creator></item><item><title>NOS cold call</title><link>http://www.nos.org.uk/forum/Topic11588-11-1.aspx</link><description>Has anyone else had a call from NOS asking for money.  Wasn't sure where they got my number from and I was quite annoyed by it.</description><pubDate>Mon, 25 Mar 2013 14:27:34 GMT</pubDate><dc:creator>Jess</dc:creator></item><item><title>BT phone scam</title><link>http://www.nos.org.uk/forum/Topic11551-11-1.aspx</link><description>Received a phone call from BT, informing me that he was disconnecting me because of an unpaid bill.. He demanded payment immediately of £31.00 or it would be £ 118.00 to re-connect at a later date. The guy wasn't even fazed when I told him I was with Virgin Media, allegedly VM have to pay BT a percentage for line rental! I asked the guy's name - he gave me the very 'English' John Peacock with a very 'African' accent - &amp; phone number -0800 0800 152. Obviously the fellow realized I didn't believe his story, so offered to demonstrate that he was from BT. I asked how &amp; he told me to hang up &amp; try phoning someone - he would disconnect my phone to prevent this. AND HE DID !! My phone was dead - no engaged tone, nothing - until he phoned me again. Very pleased with himself, he asked if that was enough proof that he was with BT. I asked how the payment was to be made &amp; he said credit card, there &amp; then. I said that I didn't know how he'd done it, but I had absolutely no intention of paying him, I didn't believe his name or that he worked for BT. He hung up. I dialed 1471 -number withheld I phoned his fictitious 0800 number - not recognized. So I phoned the police to let them know. I wasn't the first! It's only just started apparently, but it is escalating. Their advice was to let as many people as possible know of this scam. I found out a very good database here [url=http://www.tellows.co.uk/]http://www.tellows.co.uk/[/url] where I also shared my experience. The fact that the phone does go off would probably convince some people it's real, so please make as many friends &amp; family aware of this. How is it done? This is good but not that clever. He gave the wrong number - it should have been 0800 800 152 which takes you through to BT Business. The cutting off of the line is very simple, he stays on the line with the mute button on and you can't dial out - but he can hear you trying. (This is because the person who initiates a call is the one to terminate it). When you stop trying he cuts off and immediately calls back. You could almost be convinced! The sad thing is that it is so simple that it will certainly fool many. By the way this is not about getting the cash as this would not get past merchant services - it is all about getting the credit card details which include the security number, to be used for larger purchases.</description><pubDate>Tue, 19 Mar 2013 11:53:47 GMT</pubDate><dc:creator>LauraLaura</dc:creator></item><item><title>What causes psoriasis?</title><link>http://www.nos.org.uk/forum/Topic11079-11-1.aspx</link><description>Recently my friend has diagnosed with psoriasis. It is very strange for me. He don't have any kind of bad habits. What causes psoriasis?&lt;br&gt;&lt;br&gt;David</description><pubDate>Fri, 01 Feb 2013 09:37:41 GMT</pubDate><dc:creator>djones</dc:creator></item><item><title>ergocalciferol</title><link>http://www.nos.org.uk/forum/Topic11405-11-1.aspx</link><description>hiya Just wanna chat&lt;br&gt;My hubby was diagnosed with severe osteoporosis in 2010 and is now aged 51. Its been a nightmare of a game 3 years ago he had an accident at work resulting in 5 spinal fractures, but unfortunately these spinal fractures was not discovered till 2 1/2  years after the accident, although he had a lot of investigations and treatment  to try and discover why he was in a lot of pain it was not discovered until he had a full spinal scan which took some convincing to get  him to have and lie their that long.   Last year we hoped they may have operated, but the specialist said no it was too late. following second dexa scan his bone density got worse -5.5 spine and -3.2 hip, and we had to fight to have teriparamide injections as he was refused funding at first by PCT.  Although on a wide concoction of medication and calcium and vitamin D supplements he has been informed by the hospital today his vit D is severely deficient and has to take 1 ergocalciferol 1.25mg weekly to help boost vitamin D.  We are still awaiting to be contacted for delivery and treatment to start on teriparamide.  Since diagnosis he has put on a lot of weight , in pain all the while although on various pain medication, now diabetic, with high cholesterol and high blood pressure and to top it all he has been referred to a liver specialist because they think his liver problem may be drug induced. Wanted a moan sorry all, but every time you think you have a step forward you take twenty back, how do you all manage, i don't have it but i hate whats its done. Within 3 years our life has completely turned upside down. (Think i need a coping mechanism) ;(. &lt;br&gt;</description><pubDate>Thu, 07 Mar 2013 18:09:07 GMT</pubDate><dc:creator>San</dc:creator></item><item><title>Low Cholesterol Diet</title><link>http://www.nos.org.uk/forum/Topic11340-11-1.aspx</link><description>I have just had a TIA and a diagnosis of high cholesterol, my level is 9,  and I have been prescribed the relevant drugs to lower it.  Can anyone recommend the source of a sensible diet to reduce this level.  The sites on line that I've found so far are all recommending products which they sell or from wierdoes or american foods.  I am taking the meds but would like to start eating better as well.  &lt;br&gt;&lt;br&gt; I'm sure my friends on here will have some knowledge about cholesterol and I hope will post some useful advice.  I have learnt so much from everyone on the site here about my OP so maybe there's a forum for TIA and high BP and Cholesterol.  If you know of such a thing I would welcome news of it.&lt;br&gt;&lt;br&gt;Amelie</description><pubDate>Fri, 01 Mar 2013 16:56:05 GMT</pubDate><dc:creator>Amelie</dc:creator></item><item><title>I android acid side effects</title><link>http://www.nos.org.uk/forum/Topic11363-11-1.aspx</link><description>I have just been changed to this medication from pro telos as last 2 scans showed no improvement. I am really worried about the side effects of this new one. Just wondering  if the feeling that something is stuck in my throat will go after a while and same about the unsightly very red rash across my face.  From a very sad and fed up lady :(. Just noticed bad spelling. Meant ibandronic acid!</description><pubDate>Mon, 04 Mar 2013 18:59:33 GMT</pubDate><dc:creator>Jackie C</dc:creator></item><item><title>Spam posters</title><link>http://www.nos.org.uk/forum/Topic11135-11-1.aspx</link><description>Like every other genuine poster on this site I'm getting fed up with the spammers. They are on the same level as all those sleazy cold callers lying about PPI claims and insulation grants and the like. I did hear a story - not that I would ever do this of course ;) about a group of people who got back at these idiots by spamming back. What they did was go to the website and request brochures or information or whatever. Of course they didn't use their own names, but some of them got quite inventive at coming up with names and addresses and so on which expressed the opinion they held of the spammers. Others tracked down the details of the company's directors and fed that into the mix.&lt;br&gt;&lt;br&gt;These fools get too easy a time of it. This seems to be one of the few ways of conveying the message that spamming is disreputable behaviour which damages a company's reputation.&lt;br&gt;&lt;br&gt;There was a recent case of someone who started billing cold callers, took them to court for non-payment and won. I wonder if NOS could do something similar by putting that provision in forum Ts and Cs?</description><pubDate>Wed, 06 Feb 2013 15:40:15 GMT</pubDate><dc:creator>Kelly Ton</dc:creator></item><item><title>Strontium ranelate:  proposed mode of action</title><link>http://www.nos.org.uk/forum/Topic11086-11-1.aspx</link><description>I  was sent the following abstract from a 'friend' on the National Osteoporosis Foundation Forum  Inspire.   I needed to read it several times to get the gist of what I think, it is saying.   I wrongly assumed that Strontium Ranelate was made from strontium citrate, they do actually use strontium chloride and sodium ranelate. If my understanding is correct,  they showed that its the actual SR complex  which is the active agent, rather than the the strontium ions, strontium chloride or sodium ranelate.   It would be interesting if the tests were repeated using strontium citrate.   I have no idea if anyone buys strontium chloride, if so they may be wasting their money.&lt;br&gt;&lt;br&gt;&lt;br&gt;&lt;br&gt;&lt;br&gt;Mol Cell Biochem. 2012 Jan;359(1-2):399-407. doi: 10.1007/s11010-011-1034-8. Epub 2011 Aug 27.&lt;br&gt;&lt;br&gt;The intact strontium ranelate complex stimulates osteoblastogenesis and suppresses osteoclastogenesis by antagonizing NF-κB activation&lt;br&gt;&lt;br&gt;Yamaguchi M, Weitzmann MN.&lt;br&gt;Source:  Division of Endocrinology and Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, 101 Woodruff Circle, 1305 WMRB, Atlanta, GA 30322, USA. yamamasa1155@yahoo.co.jop&lt;br&gt;Abstract&lt;br&gt;&lt;br&gt;Strontium ranelate, a pharmaceutical agent shown in clinical trials to be effective in managing osteoporosis and reducing fracture risk in postmenopausal women, is relatively unique in its ability to both blunt bone resorption and stimulate bone formation. However, its mechanisms of action are largely unknown. As the nuclear factor-kappa B (NF-κB) activation antagonists both stimulate osteoblastic bone formation and repress osteoclastic bone resorption, we hypothesized that strontium ranelate may achieve its anabolic and anti-catabolic activities by modulating NF-κB activation in bone cells. In this study, osteoclast and osteoblast precursors were treated with intact strontium ranelate or its individual components sodium ranelate and/or strontium chloride, and its effect on in vitro osteoclastogenesis and osteoblastogenesis and on NF-κB activation quantified. Although the activity of strontium ranelate has been attributed to the release of strontium ions, low dose intact strontium ranelate complex, but not sodium ranelate and/or strontium chloride, potently antagonized NF-κB activation in osteoclasts and osteoblasts in vitro, and promoted osteoblast differentiation while suppressing osteoclast formation. Taken together, our data suggest a novel centralized mechanism by which strontium ranelate promotes osteoblast activity and suppresses osteoclastogenesis, based on suppression of NF-κB signal transduction. We further demonstrate that the biological actions of strontium ranelate may be related to low dose of the intact molecule rather than dissociation and release of strontium ions, as previously thought. These data may facilitate the development of additional novel pharmacological agents for the amelioration of osteoporosis, based on NF-κB blockade.&lt;br&gt;&lt;br&gt;PMID:&lt;br&gt;    21874315&lt;br&gt;    [PubMed - indexed for MEDLINE] &lt;br&gt;</description><pubDate>Fri, 01 Feb 2013 16:55:25 GMT</pubDate><dc:creator>Lynne H</dc:creator></item><item><title>Snow Shoeing/Raquettes</title><link>http://www.nos.org.uk/forum/Topic11267-11-1.aspx</link><description>This must be the best winter exercise. Snow shoeing or raquetting in the clean Alpine sunny air. Good weightbearing exercise, lots of Vit D and cardiovascular exercise ,not forgetting all that calcium rich food&lt;br&gt;&lt;br&gt; I do also go skiing on soft fluffy new snow days too but never at weekends (too busy) and not when visibility is poor and now only ski on gentler slopes. I wear padded snow boarder knickers , a light back pack stuffed with soft things and a helmet.&lt;br&gt;I feel safer on skis or "raquettes" in the Alps than I do walking around the icy wet UK. As everyone around is using ski sticks to steady themselves or ski I feel relatively normal&lt;br&gt;&lt;br&gt;&lt;br&gt;</description><pubDate>Sat, 23 Feb 2013 00:08:21 GMT</pubDate><dc:creator>flossykins</dc:creator></item><item><title>Zolendronic acid treatment</title><link>http://www.nos.org.uk/forum/Topic11183-11-1.aspx</link><description>About to have infusion acid treatment 12 monthly and am feeling nervous, what are the general opinions about it ?</description><pubDate>Tue, 12 Feb 2013 12:25:16 GMT</pubDate><dc:creator>Gretta</dc:creator></item><item><title>Physio for back pain and osteoporosis</title><link>http://www.nos.org.uk/forum/Topic8017-11-1.aspx</link><description>Have lower back pain going down both legs at times have been sent for physio but some friends say this is not good if you have Osteoporosis what do others think&lt;br&gt;</description><pubDate>Fri, 10 Feb 2012 23:11:56 GMT</pubDate><dc:creator>Isobel</dc:creator></item><item><title>Vit B12 deficiency.  You must watch this video</title><link>http://www.nos.org.uk/forum/Topic11210-11-1.aspx</link><description>&lt;br&gt;The following link was given on the National Osteo. Foundation forum in reply to a question about whether she could have a B12 deficiency, because of the classical neurological symptoms she was having, yet her blood count appeared normal..   &lt;br&gt;&lt;br&gt;The video lasts about 45 minutes and is a real eye opener.  After working in a  Haematology Lab all my life, I was trained to believe that patients would be anaemic and have an abnormal Full Blood Count in B12 deficiency. This video shows that this is not always true and many patients are misdiagnosed with a huge range of neurological conditions. They are given inappropriate treatment,  when in fact B12 injections would cure them.   &lt;br&gt;&lt;br&gt;Although it doesn't directly link to OP,  some of us take stomach medications for indigestion etc and this reduces the absorption of B12.  Another worrying  fact is that folate supplements and foods with added folate,  mask  the presence of B12 deficiency in relation to a FBC, so patients with neurological symptoms who have a normal FBC,  are not being  tested for B12 deficiency, allowing them to develop  disabling neurological / mental  symptoms, some of which are life threatening.&lt;br&gt;&lt;br&gt;This video should be  shown to all doctors and lab staff! &lt;br&gt;&lt;br&gt;&lt;br&gt;http://www.youtube.com/watch?v=BvEizypoyO0&amp;feature=player_embedded.</description><pubDate>Sat, 16 Feb 2013 17:22:15 GMT</pubDate><dc:creator>Lynne H</dc:creator></item><item><title>Ca supplements linked to mortality risk in men, but not women</title><link>http://www.nos.org.uk/forum/Topic11152-11-1.aspx</link><description>I've copied a short paper from The Heart.org.   Thought it may be of interest&lt;br&gt;&lt;br&gt;&lt;br&gt;Calcium supplements linked to mortality risk in men, but not women&lt;br&gt;February 4, 2013 Michael O'Riordan&lt;br&gt;inShare&lt;br&gt;&lt;br&gt;  Bethesda, MD - The debate over the safety of calcium supplements has been muddied with the publication of a new analysis showing that a high intake of supplemental calcium increases the risk of cardiovascular disease (CVD) death in men but not in women [1]. Compared with individuals who took no calcium, men who consumed 1000 mg or more of supplemental calcium per day had a significant 20% increased risk of CVD death, a risk that was driven by a significant 19% increased risk of heart-disease death.&lt;br&gt;&lt;br&gt;For women, however, there was no association between calcium intake and the risk of death.&lt;br&gt;&lt;br&gt;"We found a significant interaction by sex," write Dr Qian Xiao (National Cancer Institute, Bethesda, MD) and colleagues in their paper, published online February 4, 2013 in JAMA: Internal Medicine. "Elevated CVD mortality with increasing supplemental calcium intake was observed only in men; however, we cannot rule out the possibility that supplemental calcium intake may be associated with cardiovascular mortality in women." The group calls the difference in risk between men and women "intriguing," adding that further studies are needed to determine whether such differential risks are real.&lt;br&gt;&lt;br&gt;In an editorial [2], Dr Susanna Larsson (Karolinska Institute, Stockholm, Sweden) said the lack of association between calcium supplementation in women is "perplexing," especially given the results of a reanalysis of the WHI study conducted by Dr Mark Bolland (University of Auckland, New Zealand) and colleagues. In the original WHI analysis on the risks associated with calcium use, investigators found no adverse cardiovascular effects in women taking calcium and vitamin D when compared with those not taking the supplements. However, Bolland et al reexamined the WHI data because 54% of women were already taking calcium and vitamin D by personal choice at the start of the WHI study and were not told to stop if they were randomized to placebo. When the data were reanalyzed, the researchers observed a significant association between calcium intake, as well as vitamin D, with the risk of MI.&lt;br&gt;&lt;br&gt;New report from NIH data&lt;br&gt;&lt;br&gt;The latest report is taken from an analysis of the National Institutes of Health—AARP Diet and Health Study, a study that included 388 229 men and women 50 to 71 years of age from six US states. Individuals self-reported frequency of food intake and portion size during a one-year period and answered questions about the frequency in which they consumed multivitamins, calcium-containing antacids, or calcium supplements alone.&lt;br&gt;&lt;br&gt;During a mean follow-up of 12 years, there were 7904 and 3874 CVD deaths in men and women, respectively. Dietary intake of calcium was initially associated with total CVD and heart-disease death in men and women, but the association was no longer significant after adjustment for CVD risk factors. Supplemental calcium intake (1000 mg/day vs no calcium supplementation), on the other hand, increased the risk of CVD death and heart-disease death by 20% and 19%, respectively, in men, but there was no association in women. In an analysis that looked only at those taking calcium supplements and not multivitamins, the risk of CVD death and heart-disease death was 24% and 37% higher in men who took 1000 mg/day of calcium compared with those who took no supplements. Again, no association was observed in women who took calcium supplements alone.&lt;br&gt;&lt;br&gt;There is currently a debate surrounding the benefits and risks of supplemental calcium in men and women. In 2010, researchers published a meta-analysis in BMJ showing that the use of calcium supplements without coadministered vitamin D is associated with an increased risk of MI. This increased risk was later confirmed in an analysis of the patients participating in the European Prospective Investigation into Cancer and Nutrition Study (EPIC).&lt;br&gt;&lt;br&gt;In the editorial, Larsson concludes that the available evidence is suggestive of an adverse cardiovascular effect with excessive use of calcium supplements. Published as part of JAMA: Internal Medicine's series on "less is more" in medicine, the editorial states that more calcium, which is promoted because of its proposed benefits on bone health, does translate into health benefits. The best source of calcium, says Larsson, remains diet and the consumption of calcium-rich foods such as low-fat dairy, beans, and green leafy vegetables.</description><pubDate>Thu, 07 Feb 2013 18:46:29 GMT</pubDate><dc:creator>Lynne H</dc:creator></item><item><title>Calcium supplements</title><link>http://www.nos.org.uk/forum/Topic10210-11-1.aspx</link><description>I am currently on Ideos calcium supplement, one tablet twice a day.  This tablet contains calcium and vitamin D3.  I have recently been made aware, that too much calcium without magnesium can result in an elevated cholesterol level (mine is sky-high despite good diet).  Does anyone know of a supplement that also contains magnesium together with calcium and vitamin D3, or should I take a separate magnesium supplement?  I am also on Protelos - not happy taking it, but it has helped a bit and reduced my osteopenia by 0.1 in my last DEXA scan.</description><pubDate>Tue, 30 Oct 2012 12:26:52 GMT</pubDate><dc:creator>Opal</dc:creator></item><item><title>Strontium ranelate:  proposed mode of action</title><link>http://www.nos.org.uk/forum/Topic11085-11-1.aspx</link><description>&lt;br&gt;I  was sent the following abstract from a 'friend' on the National Osteoporosis Foundation Forum  Inspire.   I needed to read it several times to get the gist of what I think, it is saying.   I wrongly assumed that Strontium Ranelate was made from strontium citrate, they do actually use strontium chloride and sodium ranelate. If my understanding is correct,  they showed that its the actual SR complex  which is the active agent, rather than the the strontium ions, strontium chloride or sodium ranelate.   It would be interesting if the tests were repeated using strontium citrate.   I have no idea if anyone buys strontium chloride, if so they may be wasting their money.&lt;br&gt;&lt;br&gt;&lt;br&gt;&lt;br&gt;&lt;br&gt;Mol Cell Biochem. 2012 Jan;359(1-2):399-407. doi: 10.1007/s11010-011-1034-8. Epub 2011 Aug 27.&lt;br&gt;&lt;br&gt;The intact strontium ranelate complex stimulates osteoblastogenesis and suppresses osteoclastogenesis by antagonizing NF-κB activation&lt;br&gt;&lt;br&gt;Yamaguchi M, Weitzmann MN.&lt;br&gt;Source:  Division of Endocrinology and Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, 101 Woodruff Circle, 1305 WMRB, Atlanta, GA 30322, USA. yamamasa1155@yahoo.co.jop&lt;br&gt;Abstract&lt;br&gt;&lt;br&gt;Strontium ranelate, a pharmaceutical agent shown in clinical trials to be effective in managing osteoporosis and reducing fracture risk in postmenopausal women, is relatively unique in its ability to both blunt bone resorption and stimulate bone formation. However, its mechanisms of action are largely unknown. As the nuclear factor-kappa B (NF-κB) activation antagonists both stimulate osteoblastic bone formation and repress osteoclastic bone resorption, we hypothesized that strontium ranelate may achieve its anabolic and anti-catabolic activities by modulating NF-κB activation in bone cells. In this study, osteoclast and osteoblast precursors were treated with intact strontium ranelate or its individual components sodium ranelate and/or strontium chloride, and its effect on in vitro osteoclastogenesis and osteoblastogenesis and on NF-κB activation quantified. Although the activity of strontium ranelate has been attributed to the release of strontium ions, low dose intact strontium ranelate complex, but not sodium ranelate and/or strontium chloride, potently antagonized NF-κB activation in osteoclasts and osteoblasts in vitro, and promoted osteoblast differentiation while suppressing osteoclast formation. Taken together, our data suggest a novel centralized mechanism by which strontium ranelate promotes osteoblast activity and suppresses osteoclastogenesis, based on suppression of NF-κB signal transduction. We further demonstrate that the biological actions of strontium ranelate may be related to low dose of the intact molecule rather than dissociation and release of strontium ions, as previously thought. These data may facilitate the development of additional novel pharmacological agents for the amelioration of osteoporosis, based on NF-κB blockade.&lt;br&gt;&lt;br&gt;PMID:&lt;br&gt;    21874315&lt;br&gt;    [PubMed - indexed for MEDLINE] &lt;br&gt;</description><pubDate>Fri, 01 Feb 2013 16:52:20 GMT</pubDate><dc:creator>Lynne H</dc:creator></item><item><title>Shoes</title><link>http://www.nos.org.uk/forum/Topic10557-11-1.aspx</link><description>Can anyone recommend shoe brands that don't become slippy - I've got a great looking pair of Geox that look like they've got a nice 'grippy' tread - but no! a bit of frost or even wet pavement and they feel very slippy.</description><pubDate>Wed, 28 Nov 2012 11:19:43 GMT</pubDate><dc:creator>Jacquos</dc:creator></item><item><title>What is Osteoporosis?</title><link>http://www.nos.org.uk/forum/Topic10983-11-1.aspx</link><description>Hi all, Just wanted to know that in general like in layman term what will be the name for this Osteoporosis?&lt;br&gt;&lt;br&gt;&lt;br&gt;Thanks&lt;br&gt;David</description><pubDate>Thu, 24 Jan 2013 09:27:10 GMT</pubDate><dc:creator>djones</dc:creator></item><item><title>Does teriparatide (Forsteo/Forteo) work, and if so for how long?</title><link>http://www.nos.org.uk/forum/Topic10979-11-1.aspx</link><description>I'd like to hear from anyone who has completed the 18 to 24 month teriparatide treatment for osteoporosis.  I am trying to weigh the risk/ benefit factors of teriparatide (Forteo/Forsteo) in osteo treatment before making a decision for myself.&lt;br&gt;&lt;br&gt;If anything, what did you experience while on teriparatide?  Was the treatment effective, and to what degree?&lt;br&gt;Did you have follow-up DEXA scans? what are the results after 1 year? 2 years? 3 years? I want to know if bone laid stays, for how long?  With a bisphosphonate following? Was bone density lost again? to what degree? &lt;br&gt;&lt;br&gt;Thanks!</description><pubDate>Thu, 24 Jan 2013 04:33:00 GMT</pubDate><dc:creator>treese</dc:creator></item><item><title>Pins and needles</title><link>http://www.nos.org.uk/forum/Topic11028-11-1.aspx</link><description>Diagnosed with osteoporisis last year - fractured L4 and disc trouble between L5 and S1. - I'm doing a lot of walking and now have got pins and needles in my left buttock.....should I just wait for it to go away?</description><pubDate>Tue, 29 Jan 2013 11:03:53 GMT</pubDate><dc:creator>Jacquos</dc:creator></item><item><title>Crazy appointment!!!</title><link>http://www.nos.org.uk/forum/Topic10771-11-1.aspx</link><description>You are not going to believe this! &lt;/P&gt;&lt;P&gt;My consultant review was due in Dec and typically it was cancelled at the last minute. That was frustrating in itself as I cannot tolerate my bisphosphonates so have come off them and wanted to talk about alternative treatment.&lt;/P&gt;&lt;P&gt;You will  never guess when my new appointment has been rescheduled........?&lt;/P&gt;&lt;P&gt;July 10th!!!&lt;/P&gt;&lt;P&gt;I am stunned, and I will be calling the secretary in the New Year!!!!&lt;/P&gt;&lt;P&gt;Just felt I needed to share..:)</description><pubDate>Thu, 27 Dec 2012 16:11:16 GMT</pubDate><dc:creator>andie</dc:creator></item><item><title>Does your non- OP partner take any of your supplements?</title><link>http://www.nos.org.uk/forum/Topic10912-11-1.aspx</link><description>Have other members wondered whether their husbands/partners should take occasional supplements like D3, Mg and K2 mk-7? My 69 yr old husband is relatively fit and works with me as a volunteer at the Wildlife Hosp. I am already neurotic about my own health with having OP. A close friend of ours had a stroke a couple of weeks ago, completely out of the blue and I have started worrying about my husband in case his arteries are furring up. Could you see any potential problems in him taking supplements?&lt;br&gt;&lt;br&gt;Lynne H&lt;br&gt;&lt;br&gt;&lt;br&gt;Sorry, I put this posting in the wrong section at first and have tried to delete it</description><pubDate>Sun, 13 Jan 2013 14:22:06 GMT</pubDate><dc:creator>Lynne H</dc:creator></item><item><title>SPAM MESSAGES</title><link>http://www.nos.org.uk/forum/Topic10747-11-1.aspx</link><description>As I thought - I reported a spam message and got an automated reply from Dom saying:&lt;br&gt;&lt;br&gt;[quote]Hi, I'm out of the office on annual leave until Wednesday 2nd January and will reply to your email when I return.[/quote]&lt;br&gt;&lt;br&gt;[b]Please everyone report every single spam message so that the NOS finally gets the message that we hate this spam. It wastes my time to look up messages on forum that are simply spam.[/b] &lt;br&gt;&lt;br&gt;This forum needs proper moderating of forum members, too many spammers are able to join - that's why there are over 16,000 members of this forum - they do not all have osteoporosis, probably around 15,500 of them do NOT have osteoporosis but are simply spammers and bots trying to advertise. As I wrote in another message, I am on a diabetes forum which is ten times busier than this forum, yet there are only just over 900 members and none of them are spammers or bots as the moderators of that forum don't allow them to join. There is no policing of people when they request to join this NOS forum which is why we get all these spammers.&lt;br&gt;&lt;br&gt;</description><pubDate>Sat, 22 Dec 2012 08:03:36 GMT</pubDate><dc:creator>AnneB</dc:creator></item><item><title>Merry Christmas Everyone!</title><link>http://www.nos.org.uk/forum/Topic10761-11-1.aspx</link><description>Wishing everyone a Merry Christmas.&lt;/P&gt;&lt;P&gt;Keep safe and not too much sherry!!&lt;/P&gt;&lt;P&gt;Pink Panther.&lt;/P&gt;&lt;P&gt;:)</description><pubDate>Mon, 24 Dec 2012 15:44:27 GMT</pubDate><dc:creator>pinkpanther73</dc:creator></item><item><title>Alendronic Acid V Risedronate V Strontium Ranelate</title><link>http://www.nos.org.uk/forum/Topic10579-11-1.aspx</link><description>I read a few people's experience of Alendronic Acid, and decided I would take it a prescribed and hope it did not affect me. After taking the first 4, I was fine, but after number 5, I had burning eyes and feel as though my head is in a vice. I went to the doctors on Friday for my Dexa Scan Results, which show I am Osteopenic, Spine -2.0 and Total Hip -1.7. As I fractured my Vertebta at T12, just by coughing in August, I am deemed to be at significant risk of further fracture, and so need to take the medication. Because of my side effects with the Alendronic Acid, I discussed changing to Strontium Ranelate with my doctor, but he suggested I try Residronate Sodium as it is generally better tolerated than the Alendronic Acid. He said the side effects of Strontium is blood clots. I also take the Adcal-D3 Caplets. I truly feel that I might be better of with the Strontium Ranelate, as I do not wish to carry on feeling the way I do now, something between abject misery and Mrs negative and totally depressed. I am trying to carry on at work, but just can't concentrate. I am 58 by the way. Can anyone please help me, I think I will return to my doctors, and ask to change to Strontium, wil I be doing the right thing. Thanks in anticipation.</description><pubDate>Sun, 02 Dec 2012 12:11:34 GMT</pubDate><dc:creator>Aileen</dc:creator></item><item><title>sore throat</title><link>http://www.nos.org.uk/forum/Topic8988-11-1.aspx</link><description>Hi all, I have started alendronic acid a month ago for my OP diagnosed in Jan. suffering with terrible constipation so changed to risendronate to see what happens. I was wondering if a sore throat is a common side effect. I am not suffering from reflux but have developed a very sore throat, runny nose and I am swallowing a lot more. I mentionted it to my GP but she dismissed it as a cold. I just think its a coincidence. Back to see consultant in July to sort out meds if these are still not right for me. I am only 38 and recovering from vetebral fracture. Advice welcome</description><pubDate>Fri, 11 May 2012 14:02:27 GMT</pubDate><dc:creator>andie</dc:creator></item><item><title>Clothing</title><link>http://www.nos.org.uk/forum/Topic10575-11-1.aspx</link><description>Hello I am new to the forum please bare with me. My Mother is 80, and she has OP and developed a stoop, her bras are now very uncomfortable, she has tried on several different  designs to no avail and is feeling down.  Even her coat no longer fits it pulls up at the back and gapes at the neck.  Is there any clothing in the retail industry that would be suitable. Its bad enough having OP but are people destined to spend the rest of their lives wearing ill fitting clothing. My Mother has always taken great pride in how she looks and kept up with the latest fashion trends, Its horrible to see how disappointed she gets when clothes shopping. I would be grateful for any suggestions. Thankyou</description><pubDate>Sat, 01 Dec 2012 08:31:25 GMT</pubDate><dc:creator>jacqui</dc:creator></item><item><title>pain relief</title><link>http://www.nos.org.uk/forum/Topic10143-11-1.aspx</link><description>Ive been diagnosed with OP last year and had two fractures of the upper back spine.  Been taking different types of painkillers and only just discovered Baclofen &amp; amytryptiline as suitable painkillers in my case.  Co-codinmol didnt do anything other than make me feel worse (dizziness &amp; out of this world).  Gp now thinks Im allergic to codimol as I nearly passed out.&lt;br&gt;&lt;br&gt;I was taking baclofen for muscle spasms due to another illness however when my pain got a lot worse and I could hardly move, was told to up my doseage and hey presto its helping greatly.&lt;br&gt;&lt;br&gt;Just wanted to share ;)&lt;br&gt;&lt;br&gt;bren</description><pubDate>Sun, 21 Oct 2012 15:38:24 GMT</pubDate><dc:creator>yawn</dc:creator></item><item><title>Exercise - Skipping</title><link>http://www.nos.org.uk/forum/Topic4574-11-1.aspx</link><description>Does anyone know if this would be ok for osteopenic and other as my signature info below.&lt;br&gt;&lt;br&gt;Thinking of maybe including a daily routine of skipping. Working up to about 40 skips a day or more.  At the moment I am only doing skips once a week in exercise class [i]6 right leg leading, 6 left leg leading then up to 10 skip jumps (both legs together)[/i]&lt;br&gt;&lt;br&gt;I'm not sure if skipping will be ok for my personal situation.&lt;br&gt;&lt;br&gt;Thanks for any input.&lt;br&gt;&lt;br&gt;</description><pubDate>Mon, 04 Apr 2011 19:27:32 GMT</pubDate><dc:creator>OJ</dc:creator></item><item><title>Not what you would expect....</title><link>http://www.nos.org.uk/forum/Topic10098-11-1.aspx</link><description>....but OP actually gets a mention right at the end of this takeoff of the Felix Baumgartner skydive :D&lt;br&gt;&lt;br&gt;http://mashable.com/2012/10/17/slim-jim-executes-the-worlds-shortest-freefall-video/</description><pubDate>Wed, 17 Oct 2012 10:56:21 GMT</pubDate><dc:creator>Kelly Ton</dc:creator></item><item><title>Vertebral fracture 10 months on.</title><link>http://www.nos.org.uk/forum/Topic9958-11-1.aspx</link><description>Hi all, any help out there? I am 39 with OP and suffered fracture of T12 last nov from minor accident. No other risk factors for OP, but have had 5 fractures in 3 years. On Risedronate now. I am really struggling with my back at the moment. I am single parent of 6 and 3 year old and now have part time job in M&amp;amp;S at weekends. The standing at work is excruciating and taking me all week to recover. I am so worried I may have another compression fracture in lumbar area, or is it simply mechanical and soft tissues issues following fracture last year??? Can I sustain another fracture without trauma?? I am constantly lifting and moving with the children but its become unbearable since I started back at work. What can I do? I have had physio and pilates. Not overweight and keep healthy. Its awful living with pain everytime I move. Seeing GP tomorrow. Worried!!!</description><pubDate>Mon, 24 Sep 2012 14:07:19 GMT</pubDate><dc:creator>andie</dc:creator></item><item><title>new chat topic!</title><link>http://www.nos.org.uk/forum/Topic9928-11-1.aspx</link><description>Just wanting to start a new topic here that's more positive in nature....&lt;/P&gt;&lt;P&gt;so, I'm typing to a bunch of people from across the pond, as we sometimes say here. I'm curious how your nhs works. We have government health here but it doesn't cover Physiotherapists or Dentists or prescriptions... And, each province is different...</description><pubDate>Mon, 17 Sep 2012 18:15:19 GMT</pubDate><dc:creator>elise52</dc:creator></item><item><title>For the attention of the moderator - a welcome message to new forum members</title><link>http://www.nos.org.uk/forum/Topic9875-11-1.aspx</link><description>Hi Dylan,&lt;br&gt;&lt;br&gt;As you might remember, I own/moderator a forum for parents with children on the autistic spectrum. When new members join the forum an automatic message is sent from me welcoming them to the forum and giving a few basic suggestions. I was wondering why you don't do the same as I notice these past few days that that you are writing a welcome message to new forum members and always suggesting they phone the NOS Helpline. To be honest, when I was first diagnosed with osteoporosis I went to the NOS Helpline which was invaluable and THEN I went to the then forum because I wanted to talk with others about their experiences of osteoporosis. If you had an automatic welcoming message with the suggestion to go to the Helpline it would be less of a put down on forum members because I do feel that your message is a put down - it's like you're saying welcome to the forum but why don't you go to the Helpline instead ! I know we forum members sometimes suggest a new member contacts the NOS Helpline but when we do that it is from our own experiences of contacting the Helpline and finding it useful.</description><pubDate>Tue, 04 Sep 2012 11:32:41 GMT</pubDate><dc:creator>AnneB</dc:creator></item></channel></rss>